Heterocyclic compounds are cyclic compounds containing one or more atom(s) of other elements along with carbon atoms in the ring system. Nitrogen, sulfur, and oxygen are the most typical heteroatoms. They are widely distributed in nature and are vital to our life.1Heterocyclic compounds may be classified into aliphatic or aromatic. The aromatic heterocyclic compounds are those which have a heteroatom in the ring and resemble benzene in some of their properties. Benzothiazole is aromatic heterocyclic compound. The basic structure of benzothiazole consists of a benzene ring fused with thiazole. Thiazole is a 5 membered ring system contains both nitrogen and sulfur.   These two rings together constitute the basic nucleus 1, 3- benzothiazole. The numbering in thiazole starts from sulfur.2 Benzothiazole moiety is an important component of heterocyclic compounds. These compounds possess diverse biological activity such as antimicrobial, antitubercular, antitumor, antimalarial, anticonvulsant, anthelmintic, analgesic and anti-inflammatory activity. Due to their biological and pharmacological properties, they are considered important for the synthesis of heterocyclic compound.3  Fig. 1: Chemical structure of 1, 3-benzothiazoleBenzothiazole is a bicyclic ring system with chemical formula C7H5NS (Fig. 1). It is a weak base, having a variety of biological activities and still having great scientific interest in modern days. They are widely found in the field of bioorganic and medicinal chemistry with application in new drug development.4The study of these privileged structures in drug discovery is a rapidly emerging in the field of medicinal chemistry. BIOLOGICAL ACTIVITYAnticancer activity • Eshkil F et al., (2017) synthesized some thiourea derivatives of benzothiazoles and screened for their anticancer activity.5 (a) R = H (b) R = CH3 (c) R = OCH3 (d) R = OEtFig. 2• Uremis MM et al.,(2017) carried out synthesis, characterization, in vitro antiproliferative and cytotoxicity effects of a new class of 2-((1R, 2S) -2-((E)-4- substituted styryl) cyclooctyl)benzodthiazole derivatives by  the reaction of 10-(4-substituted benzylidene)bicyclo6.2 decan-9-ones with 2- aminothiophenol in the presence of p-TsOH .6

Written by
admin
x

Hi!
I'm Colleen!

Would you like to get a custom essay? How about receiving a customized one?

Check it out